Calcium D-Glucarate, provided by Douglas Laboratories, is a natural supplement of D-glucaric acid bound to calcium.
Calcium D-glucarate enhances the body’s natural defenses against environmental toxins and excess steroid
hormones. Through the actions of its metabolite D-glucaro-1,4-lactone, calcium-d-glucarate indirectly favors
glucuronidation, an important system that the body relies upon to deactivate and eliminate toxins and steroid
Glucuronidation is a conjugation process through which potentially carcinogenic environmental toxins, such as
polycyclic aromatic hydrocarbons and nitrosamines, and excess steroid hormones are neutralized. During
glucuronidation, the enzyme glucuronosyl transferase catalyzes the conjugation of free carcinogens and
steroid hormones to glucuronic acid. The resulting glucuronide-bound toxins and hormones can then be safely
excreted in bile and urine.
The body also deconjugates glucuronide-bound end products. The release of glucuronide-bound substances
is beneficial in some circumstances, for example, when the excretion of steroid hormones is undesirable. Yet,
the deconjugation process, which works via the enzyme beta-glucuronidase, can result in the re-release of
harmful toxins back into the body. The benefits of calcium D-glucarate are realized indirectly through the
action of its metabolite D-glucaro-1,4-lactone, which inhibits the deconjugating enzyme beta-glucuronidase
found in both blood and tissue. Inhibition of beta-glucuronidase causes a net increase in glucuronidation, and
thereby enhances a primary detoxification pathway in the body. Animal studies have documented a decrease
in B-glucuronidase activity in breast, liver, colon, skin, lung, and prostate tissue following oral administration of
calcium D-glucarate. Once ingested, calcium D-glucarate is converted to D-glucaric acid in the presence of
gastric HCl. The body normally maintains an equilibrium between D-glucaric acid and its two metabolites, Dglucaro-1,4-lactone
Calcium D-glucarate provides a slow-release source of D-glucaro-1,4-lactone. When taken directly, D-glucaro-
1,4-lactone is metabolized quite quickly and is excreted from the body usually within 1-2 hours of its
administration. Calcium D-glucarate, however, is metabolized slowly, remaining in the body for 5 or more
hours after ingestion. This results in maintenance of stable levels of D-glucaro-1,4-lactone for long periods of
time. D-glucaric acid is produced endogenously in small amounts. It is also present in some fruits and
vegetables, including oranges, apples, grapefruit, broccoli and other cruciferous vegetables.
Calcium D-Glucarate may be a useful dietary supplement for those who wish to supplement their diet with D-glucaric acid as a precursor to D-glucaro-1, 4-lactone.
Serving Size 1 Capsules
Servings Per Container 90
Amount Per Serving
Calcium 63 mg (From 500 mg Calcium D-Glucarate)
Gelatin (capsule), cellulose, water and magnesium stearate.
One to two capsules daily as a dietary supplement, or as directed by physician.
No adverse effects have been reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children.