Alpha-Lipoic Acid tablets, provided by Douglas Laboratories®, contain 100 mg of pure alpha-lipoic acid.Alpha-lipoic acid is a non-vitamin coenzyme that carries out important metabolic and antioxidant functions inthe body.
Alpha-lipoic acid is a nutritional coenzyme that is involved in energy metabolism of proteins, carbohydrates andfats, has physiological functions in blood glucose disposal, and is able to scavenge a number of free radicals.Alpha-lipoic acid is a fat- and water-soluble, sulfur-containing coenzyme. It functions in the body much like aB-vitamin, since it is involved in energy production. As part of several multi-enzyme complexes located in themitochondria, alpha-lipoic acid is essential for metabolizing carbohydrates, proteins, and fats, and for theconversion of their energy into ATP. Two of these enzyme complexes, PDH (pyruvate dehydrogenase) andalpha-KGDH (alpha-ketoglutarate dehydrogenase) are part of the citric acid cycle (Krebs cycle), and as suchassume a central role for general energy production. Another lipoic acid containing enzyme complex,BCKADH (branched-chain keto-acid dehydrogenase), is involved in deriving energy from the branched chainamino acids, leucine, isoleucine, and valine. A related metabolic function of alpha-lipoic acid is its role in bloodglucose disposal. This important coenzyme appears to be necessary for the normal transport of blood glucoseinto the cell. This may be explained by its functions in the glucose-metabolizing enzymes, PDH and alphaKGDH,but some researchers suspect a more direct role in cellular glucose uptake at the cell membrane.As early as 1959, alpha-lipoic acid was suggested to be an antioxidant, since it could extend the actions ofvitamin C in guinea pigs, and those of vitamin E in rats. It is only recently, however, that the specific actions ofalpha-lipoic acid in free radical quenching, metal chelation, and antioxidant regeneration have beeninvestigated. Body cells and tissues are threatened continuously by damage caused by toxic free radicals andreactive oxygen species (e.g., peroxides) which are produced during normal oxygen metabolism, and by toxicagents in the environment. Free radicals, once formed, are capable of disrupting metabolic activity and cellstructure. When this occurs, additional free radicals are produced which, in turn, can result in more extensivedamage to cells and tissues. The uncontrolled production of free radicals is thought to be a major contributingfactor to many degenerative diseases. Alpha-lipoic acid is unique among biological antioxidants, because it issoluble in both water and lipids. This allows it to neutralize free radicals just about everywhere in the body,inside and outside the cells. Due to its unique sulfur-containing structure, alpha-lipoic acid can scavengeseveral types of free radicals, such as the highly reactive hydroxyl, and singlet oxygen free radicals. It is alsocapable of suppressing the generation of free radicals in the first place, since alpha-lipoic acid chelatestransition metals, such as iron and copper. Because alpha-lipoic acid is involved in so many differentantioxidant functions in virtually all body tissues, it has been called the universal antioxidant.Besides being a universal free radical scavenger, alpha-lipoic acid can also recharge other antioxidantsystems throughout the body. As mentioned earlier, it can extend the activity of vitamins C and E. In addition,alpha-lipoic acid can also regenerate glutathione.
Alpha-lipoic acid may be a beneficial dietary supplement for those concerned about a more completeantioxidant defense system and maintaining proper glucose metabolism. Dietary and supplementary alphalipoicacid is efficiently absorbed, transported to the tissues, and readily taken up by the cells.
Serving Size 1 Capsule
Servings Per Container 60
Amount Per Serving
Alpha-Lipoic Acid 100 mg
Other ingredients: Cellulose, stearic acid, silica and magnesium stearate.
Adults take 1 capsule daily or as directed by a healthcare professional.
No adverse side effects have been reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children.